If you know you may need to change or cancel your flight itinerary, consider using a card for the tickets that offers no change/cancel fees. A card that offers flexibility is the Chase Southwest Airlines Rapid Rewards Premier Card.
With the Southwest card, you can earn Rapid Rewards points and you won’t be charged a fee if you need to change your flight. Note, you may need to pay the difference in fare. You can learn more about the Chase Southwest Airlines Rapid Rewards Premier Card here.